(IncobotulinumtoxinA) Xeomin® was approved for use in 2010 and is manufactured by Merz. It is the lowest strength of the neuromodulators on the market and is ideal for patients who want to retain some muscle movement. Xeomin® does not contain the protective proteins that Botox and Jeuveau® do and can therefore be used in patients who have developed BOTOX® resistance. This also means it does not need to be refrigerated and may be slightly more comfortable to have injected because it is stored at room temperature.